Meds That Cause Acute Kidney Injury

Acute kidney injury is a serious medical condition that can cause life-threatening complications. It’s important to know the symptoms and how to treat it, as well as what meds are associated with acute kidney injury.

Acute kidney injury is a condition that occurs when the kidneys are damaged in a short period of time. The top 10 drugs that cause kidney damage include: methotrexate, furosemide, aminoglycosides, diuretics, NSAIDs, ACE inhibitors, and thiazides.

This Video Should Help:

If you’re like most people, you probably think of kidney stones as something that happens to other people. But the truth is, kidney stones can cause a lot of serious health problems ufffd including acute kidney injury (AKI). So if you’re ever worried about your kidneys, it’s important to know about the drugs that can cause AKI and the symptoms to watch for. In this blog post, we’ll talk about some of these drugs and how they might cause AKI. We’ll also provide a Nephrotoxic Drugs List PDF so you can learn more about which medications are potentially harmful to your kidneys.


The kidney is a vital organ that helps to filter waste and excess fluids from the blood. However, certain drugs can cause nephrotoxicity, or damage to the kidneys. This can lead to acute kidney injury (AKI), which is a sudden decline in kidney function. AKI can be serious and even life-threatening. There are many different drugs that can cause nephrotoxicity, so it is important to be aware of the signs and symptoms of AKI and to know which drugs may put you at risk.

Types of drugs that can cause nephrotoxicity

There are many different types of drugs that can cause nephrotoxicity. Some of the most common include:

1) Antibiotics: These drugs can damage the kidney by causing inflammation and scarring. They may also increase the risk of infection.

2) Cancer chemotherapy agents: These drugs can damage the kidney by interfering with its ability to filter waste products from the blood.

3) Non-steroidal anti-inflammatory drugs (NSAIDs): These drugs can damage the kidney by causing inflammation and scarring. They may also increase the risk of bleeding or ulcers in the digestive tract.

4) ACE inhibitors: These drugs can damage the kidney by causing it to retain salt and water. This can lead to high blood pressure and fluid retention.

5) ARBs: These drugs can damage the kidney by causing it to retain salt and water. This can lead to high blood pressure and fluid retention.

Mechanism of action

Drug-induced nephrotoxicity is typically caused by one of two mechanisms: direct renal toxicity or indirect renal toxicity. Direct renal toxicity occurs when the drug directly damages the kidney cells, while indirect renal toxicity occurs when the drug causes damage to other organs or systems that then results in kidney damage. Common examples of drugs that can cause direct renal toxicity include NSAIDs, ACE inhibitors, and certain antibiotics. Indirect renal toxicity is most often seen with drugs that cause liver damage, as this can lead to impaired function of the liver and subsequent kidney damage.


The symptoms of drug-induced nephrotoxicity can vary depending on the specific drug or drugs involved. In general, however, the most common symptoms include:

ufffd Increased thirst

ufffd Frequent urination

ufffd Swelling in the hands, feet, ankles, legs, or abdomen

ufffd Weight gain due to fluid retention

ufffd Fatigue and lethargy

ufffd Nausea and vomiting ufffd Muscle cramps or weakness

If you are taking a medication that you think may be causing nephrotoxicity, it is important to speak with your doctor right away. They will be able to determine if the drug is indeed causing the problem and make appropriate changes to your treatment plan.


The diagnosis of drug-induced nephrotoxicity can be difficult, as it often requires a detailed history and review of medications. In some cases, kidney function tests may be abnormal in the absence of other symptoms. If there is suspicion for drug-induced nephrotoxicity, your healthcare provider may recommend stopping the offending medication and starting another one.


There are a few different ways to treat drug-induced nephrotoxicity. The first is to simply stop taking the offending medication. This may not be possible or desirable in all cases, so other options include changing to a different medication, reducing the dosage of the current medication, or adding another medication to help protect the kidneys. Some medications can also help improve kidney function and reduce inflammation.


There are a few things you can do to prevent drug-induced nephrotoxicity. First, be sure to drink plenty of fluids throughout the day. This will help keep your kidneys flushed and free from toxins. Second, avoid taking any over-the-counter medications without first checking with your doctor or pharmacist. Some of these medications, such as ibuprofen and naproxen, can cause kidney damage if taken in large doses or for extended periods of time. Finally, if you are taking any prescription medications, be sure to follow your doctor’s instructions carefully. Take the medication exactly as prescribed and do not skip any doses. If you have any questions about a medication, be sure to ask your doctor or pharmacist before taking it.


Drug-induced nephrotoxicity is a serious problem that can lead to acute kidney injury (AKI) and chronic kidney disease. There are many different medications that can cause nephrotoxicity, so it is important to be aware of the potential risks when taking any medication. If you experience any symptoms of AKI or chronic kidney disease, be sure to seek medical attention immediately.

Frequently Asked Questions

What medications can cause acute kidney injury?

drugs that may result in acute kidney injury Antibiotics. certain drugs to lower blood pressure. medications for the treatment of cancer (chemotherapy). Dyes (contrast media). illicit drugs drugs that are used to treat HIV. medicines that are non-steroidal anti-inflammatory. medications for ulcers.

Which group of drugs is associated with acute kidney injury?

According to a research with a pediatric audience, beta-lactam antibiotics, glucocorticoids, non-steroidal anti-inflammatory medicines (NSAID), and opioids all raised the risk of acute kidney injury (AKI) in intensive care unit (ICU) kids who experienced it [23

What is the most common cause of acute kidney injury?

Reduced blood supply to the kidneys is the main factor in the majority of instances of AKI, which often affect people who are already ill due to another medical condition. Low blood volume after bleeding, extensive vomiting or diarrhea, or severe dehydration might all be contributing factors to this decreased blood flow.

Which medication is most likely to cause nephrotoxicity?

Antiplatelet medications (e.g., clopidogrel [Plavix], ticlopidine [Ticlid]), cyclosporine, mitomycin-C (Mutamycin), and quinine are those most often linked to this pathogenic mechanism of nephrotoxicity (Qualaquin)

Which drugs should be stopped in AKI?

As a result, clinicians treating patients with AKI routinely discontinue blood pressure-lowering medications, notably ACEI and ARBs that specifically decrease glomerular pressure. Because to hyperkalemia, ACEIs, ARBs, and potassium-sparing diuretics may also be discontinued.

Can blood pressure meds cause kidney damage?

According to a research, long-term usage of blood pressure medications may harm the kidneys. Concerns about the possibility that ACE inhibitors and other medications often taken to treat high blood pressure and heart failure may be causing kidney damage are being raised by new studies on the subject.

What medications cause high creatinine levels?

There have been reports of a number of medications, including cimetidine, trimethoprim, corticosteroids, pyrimethamine, phenacemide, salicylates, and active vitamin D metabolites, increasing plasma creatinine without affecting the glomerular filtration of the substance.

Can ibuprofen cause acute kidney failure?

Ibuprofen is an NSAID (non-steroidal anti-inflammatory medicine) that has been linked to a number of renal disorders, including acute renal failure. It is believed that NSAID-induced acute renal insufficiency only occurs in clinical settings when prostaglandins are required for renal blood flow (RBF) maintenance.

How do you get an acute kidney injury?

What results in sudden kidney damage? Your kidneys may get damaged for three main reasons: a lack of blood flow, an obstruction in urine flow that results in infections, or direct kidney damage brought on by infections, drugs, toxins, or autoimmune diseases.

Is AKI always reversible?

When the underlying insult is treated promptly, the majority of pre-renal AKI patients fully recover; however, if the underlying insult persists and causes acute tubular necrosis, the damage may not fully heal.

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